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PAMP-12 is an endogenous peptide and potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM) that induces hypotension by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells.
| Molecular Weight | 1619.91 |
| Formula | C77H118N24O15 |
| CAS Number | 929905-12-4 |
| Form | Solid |
| Solubility (25°C) | Water 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| (S)-ZINC-3573
(S)-ZINC-3573 is an inactive enantiomer of ZINC-3573 and a selective MRGPRX2 agonist. In addition, (S)-ZINC-3573 and (R)-ZINC-3573 are potent internal control probes that can be used to study the biology of unique receptors in primates. |
| MRGPRX4 modulator-2
MRGPRX4 modulator-2 is a potent MRGPR X4 modulator with antagonistic activity against MRGPRX4 and an IC50 < 100 nM.MRGPRX4 modulator-2 can be used in studies related to autoimmune diseases. |
| MRGPRX4 modulator-1
MRGPRX4 modulator-1 is a potent MAS-associated G-protein receptor X4 (MRGPRX4) modulator with antagonistic activity against MRGPR4 and an IC50 < 100 nM.MRGPRX4 modulator-1 can be used in studies related to MRGPRX4-dependent disorders, such as itch, pain, and autoimmune diseases. |
| MRGPRX1 agonist 1
MRGPRX1 agonist 1 is a potent Mas-related G protein-coupled receptor X1 (MRGPRX1) agonist with an EC50 value of 50 nM and is inactive against MRGPRC11. |
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