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PACAP (1-38)

Cat. No. M10161
PACAP (1-38) Structure
Size Price Availability Quantity
1mg USD 175  USD175 In stock
5mg USD 525  USD525 In stock
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Quality Control & Documentation
Biological Activity

PACAP (1-38) is a highly potent PACAP receptor agonist (Kd = 100 pM), it stimulates adenylate cyclase and phagocytosis. PACAP (1-38) dramatically prevents injury of cultured renal proximal tubule cells caused by myeloma light chains through suppression of proinflammatory cytokines production, by inhibiting p38 MAPK and translocation of NFκB via both PAC1 and VPAC1 receptors. PACAP (1-38) inhibits myeloma cell growth directly and may also indirectly by suppressing production of the growth factor, IL-6, from bone marrow stromal cells, that is stimulated by adhesion of myeloma cells.

Sequence: His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2

Chemical Information
Molecular Weight 4534.26
Formula C203H331N63O53S1
CAS Number 137061-48-4
Solubility (25°C) Water 100 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dora Werling, et al. Int J Mol Sci. Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents

[2] P Gourlet, et al. Eur J Pharmacol. Fragments of pituitary adenylate cyclase activating polypeptide discriminate between type I and II recombinant receptors

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