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OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM.
Molecular Weight | 428.97 |
Formula | C23H24N2O2S.HCl |
CAS Number | 1338545-07-5 |
Form | Solid |
Solubility (25°C) | DMSO 80 mg/mL Water 1 mg/mL (Need ultrasonic) |
Storage | 2-8°C, dry, sealed |
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