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Osocimab

Cat. No. M24894
Osocimab Structure
Synonym:

BAY 1213790

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Quality Control & Documentation
Biological Activity

Osocimab (BAY 1213790), an anti-FXIa antibody (Ki=2.4 nM; EC50=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects.

Chemical Information
CAS Number 2056878-75-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] James C Fredenburgh, et al. J Thromb Haemost. News at XI: moving beyond factor Xa inhibitors

[2] Mattia Galli, et al. Thromb Haemost. Factor XI Inhibitors in Early Clinical Trials: A Meta-analysis

[3] Antonio Gómez-Outes, et al. Expert Opin Pharmacother. Pharmacotherapy for stroke prevention in nonvalvular atrial fibrillation: current strategies and future directions

[4] Craig J Beavers, et al. J Cardiovasc Pharmacol. Osocimab: A Novel Agent in Preventing Venous Thromboembolism

[5] Jeffrey I Weitz, et al. JAMA. Effect of Osocimab in Preventing Venous Thromboembolism Among Patients Undergoing Knee Arthroplasty: The FOXTROT Randomized Clinical Trial

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  Catalog
Abmole Inhibitor Catalog




Keywords: Osocimab, BAY 1213790 supplier, Factor Xa, inhibitors, activators


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