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Osimertinib dimesylate

Cat. No. M14132
Osimertinib dimesylate Structure
Synonym:

AZD-9291 dimesylate; Mereletinib dimesylate

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Osimertinib dimesylate (AZD-9291 dimesylate) is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 and 1 nM against EGFRL858R and EGFRL858R/T790M, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 691.82
Formula
CAS Number 2070014-82-1
Purity >99%
Solubility Water 90 mg/mL
DMSO 2.63 mg/mL
Storage 2-8°C, dry, sealed
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Keywords: Osimertinib dimesylate, AZD-9291 dimesylate; Mereletinib dimesylate supplier, EGFR/HER2, inhibitors

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