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ONO-7475

Cat. No. M10497

All AbMole products are for research use only, cannot be used for human consumption.

ONO-7475 Structure
Synonym:

ONO7475

Size Price Availability Quantity
5mg USD 170  USD170 In stock
10mg USD 270  USD270 In stock
25mg USD 540  USD540 In stock
50mg USD 850  USD850 In stock
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Quality Control & Documentation
Biological Activity

ONO-7475 is a potent and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).

Mice fed a diet containing ONO-7475 exhibited significantly longer survival and, interestingly, blocked leukemia cell infiltration in the liver. In summary, ONO-7475 effectively kills acute myeloid leukemia cells in vitro and in vivo by mechanisms that involve disruption of diverse survival and proliferation pathways.

Protocol (for reference only)
Cell Experiment
Cell lines MOLM13, MV4;11, HL60, OCI-AML3, MOLM13 luc/gfp cells, MOLM13 p53 shRNA cells, BM-MSC
Preparation method MOLM13 and MV4;11 (FLT3 ITD) and OCI-AML3 (FLT3 WT) cells are incubated with vehicle (0.1% DMSO) or varying doses of ONO-7475 for 48 hours. Viable cell number and apoptosis are measured by flow cytometry.
Concentrations 50-500 nM
Incubation time 24 h, 48 h, 72 h
Animal Experiment
Animal models 4-week old female NSG mice bearing MOLM13 cells
Formulation diet containing 0.004% and 0.013% ONO-7475
Dosages 6 mg/kg, 20 mg/kg
Administration Oral gavage
Chemical Information
Molecular Weight 562.57
Formula C32H26N4O6
CAS Number 1646839-59-9
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Naoko Okura, et al. Clin Cancer Res. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non-Small Cell Lung Cancer

[2] Peter P Ruvolo, et al. Haematologica. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

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Keywords: ONO-7475, ONO7475 supplier, TAM Receptor, inhibitors, activators

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