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NVP-DPP-728 dihydrochloride

Cat. No. M9575
NVP-DPP-728 dihydrochloride Structure
Synonym:

NVP-728 2HCl

Size Price Availability Quantity
10mg USD 200  USD200 In stock
25mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

NVP-DPP-728 dihydrochloride is a potent and selective dipeptidyl peptidase IV inhibitor. NVP-DPP-728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. NVP-DPP-728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats.

Chemical Information
Molecular Weight 371.27
Formula C15H18N6O.2HCl
CAS Number 247016-69-9
Solubility (25°C) Water ≥ 40 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hironobu Mitani, et al. Jpn J Pharmacol. Dipeptidyl Peptidase IV Inhibitor NVP-DPP728 Ameliorates Early Insulin Response and Glucose Tolerance in Aged Rats but Not in Aged Fischer 344 Rats Lacking Its Enzyme Activity

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Keywords: NVP-DPP-728 dihydrochloride, NVP-728 2HCl supplier, DPP-4, inhibitors, activators

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