Free shipping on all orders over $ 500

NVP-DPP-728 dihydrochloride

Cat. No. M9575
NVP-DPP-728 dihydrochloride Structure
Synonym:

NVP-728 2HCl

Size Price Availability Quantity
10mg USD 200  USD200 In stock
25mg USD 450  USD450 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

NVP-DPP-728 dihydrochloride is a potent and selective dipeptidyl peptidase IV inhibitor. NVP-DPP-728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. NVP-DPP-728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats.

Chemical Information
Molecular Weight 371.27
Formula C15H18N6O.2HCl
CAS Number 247016-69-9
Solubility (25°C) Water ≥ 40 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hironobu Mitani, et al. Jpn J Pharmacol. Dipeptidyl Peptidase IV Inhibitor NVP-DPP728 Ameliorates Early Insulin Response and Glucose Tolerance in Aged Rats but Not in Aged Fischer 344 Rats Lacking Its Enzyme Activity

Related Dipeptidyl Peptidase Products
BI 1291583

BI 1291583 is a novel selective inhibitor of cathepsin C (CatC; DPP1). BI 1291583 bound human CatC (DPP1) in a covalent, reversible manner, selectively and fully inhibiting CatC enzymatic activity.

HAEGT

HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr.

Diprotin B

Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor.

Azaleatin

Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity.

Sitagliptin fenilalanil hydrochloride

Sitagliptin fenilalanil hydrochloride is a dipeptidyl aminopeptidase 4 (DPP-4) inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: NVP-DPP-728 dihydrochloride, NVP-728 2HCl supplier, Dipeptidyl Peptidase, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.