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NVP-DPP-728 dihydrochloride is a potent and selective dipeptidyl peptidase IV inhibitor. NVP-DPP-728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. NVP-DPP-728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats.
| Molecular Weight | 371.27 |
| Formula | C15H18N6O.2HCl |
| CAS Number | 247016-69-9 |
| Solubility (25°C) | Water ≥ 40 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Related Dipeptidyl Peptidase Products |
|---|
| Gly-Pro-pNA hydrochloride
Gly-Pro-pNA hydrochloride is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase IV and dipeptidyl peptidase IX. Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors. |
| BI 1291583
BI 1291583 is a novel selective inhibitor of cathepsin C (CatC; DPP1). BI 1291583 bound human CatC (DPP1) in a covalent, reversible manner, selectively and fully inhibiting CatC enzymatic activity. |
| HAEGT
HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. |
| Diprotin B
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. |
| Azaleatin
Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity. |
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