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NUC-7738

Cat. No. M10487
NUC-7738 Structure
Synonym:

NUC7738

Size Price Availability Quantity
10mg USD 800  USD800 In stock
25mg USD 1600  USD1600 In stock
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Quality Control & Documentation
Biological Activity

NUC-7738 is an effective pro-apoptotic agent in cancer cells with effects on the NF-kappaB pathway. NUC-7738 induced a cytotoxic effect on a wide range of cancer cell lines with an IC50 in the low uM range (<10 uM). NUC-7738 has been well tolerated and has demonstrated encouraging signals of anti-cancer activity in solid tumours.

Chemical Information
Molecular Weight 568.52
Formula C26H29N6O7P
CAS Number 2348493-39-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hagen Schwenzer, et al. Clin Cancer Res. The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial

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