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nor-NOHA acetate is a specific and reversible inhibitor of rat liver arginase. nor-NOHA could inhibit the proliferation and induce the apoptosis of HepG2 cells. nor-NOHA was also able to decrease the expression levels of Arg1 and MMP-2, increase the expression levels of P53 and ECD as well as the production of NO. In vivo, nor-NOHA treatment could fully restore the aortic response to Ach to that of healthy rats.
| Molecular Weight | 296.28 |
| Formula | C9H20N4O7 |
| CAS Number | 1140844-63-8 |
| Form | Solid |
| Solubility (25°C) | Water ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Arginase Products |
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| BEC
BEC, an arginine analogue, is a slow-binding competitive inhibitor of the binuclear manganese metalloenzyme arginase. |
| Nor NOHA hydrochlorate
Nor NOHA hydrochlorate is a specific and reversible inhibitor of arginase, which induces apoptosis in ARG2-expressing cells under hypoxic conditions. It has antileukemic activity. |
| Lacto-N-fucopentaose III
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. |
| ARG1-IN-1 hydrochloride
ARG1-IN-1 hydrochloride is a human arginase 1 inhibitor with an IC50 of 29 nM. |
| OATD-02
OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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