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Nomilin is a compound of the limonin class obtained from citrus extracts. Nomilin is an anti-obesity and anti-sugar compound. Nomilin significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown. Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of tight junction proteins, including ZO-1 and occludin-5.
| Molecular Weight | 514.56 |
| Formula | C28H34O9 |
| CAS Number | 1063-77-0 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 4°C, protect from light |
[4] Ryuichiro Sato. Nomilin as an anti-obesity and anti-hyperglycemic agent
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