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Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension. Nitrendipine and BRL 38227 cause concentration-related inhibitions of the inositol phosphate response to histamine (100 uM). Similar maximal inhibitions were caused by each agent (55-58%). Inhibitory effect of BRL 38227 was reduced in potency (IC50 = 5.5 uM), but not magnitude, in the presence of glibenclamide (0.5 uM). <
| Molecular Weight | 360.37 |
| Formula | C18H20N2O6 |
| CAS Number | 39562-70-4 |
| Solubility (25°C) | DMSO 48 mg/mL |
| Storage | 4°C, protect from light |
[3] A Zanchetti. Nitrendipine and ACE inhibitors
[4] U L Hulthn, et al. Review of long-term trials with nitrendipine
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