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Niraparib metabolite M1

Cat. No. M28521

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Niraparib metabolite M1 Structure
Synonym:

Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib

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Quality Control & Documentation
Biological Activity

Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.

Chemical Information
Molecular Weight 321.37
Formula C19H19N3O2
CAS Number 1476777-06-6
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Margarida L F Martins, et al. Mol Pharm. P-Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor Niraparib

[2] Lotte van Andel, et al. Invest New Drugs. Human mass balance study and metabolite profiling of 14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer

[3] L van Andel, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine

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Keywords: Niraparib metabolite M1, Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

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