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(-)-Nicotine ditartrate

Cat. No. M2882
(-)-Nicotine ditartrate Structure
Size Price Availability Quantity
10mg USD 68  USD68 In stock
50mg USD 135  USD135 In stock
100mg USD 220  USD220 In stock
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Biological Activity

(-)-Nicotine ditartrate is a potent nicotinic acetylcholine receptor (nAChR) agonist. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions. Nicotine reduces beta-amyloidosis in a mouse model of Alzheimer's disease. (Ki values are 16.1 (α4β2), 2110 (α7), 520 (α3β4), 270 (α6/α4β4) and 2090 nM (α1β1γδ)).

Chemical Information
Molecular Weight 462.4
Formula C10H14N2.2C4H6O6
CAS Number 65-31-6
Solubility (25°C) Soluble in water to 100 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Baeksun Kim, et al. Behav Brain Funct. Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence

[2] Rollema H, et al. Br J Pharmacol. Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence.

[3] Claudio Coddou, et al. Philos Trans R Soc Lond B Biol Sci. Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice

[4] Coolon RA, et al. Behav Pharmacol. Individual differences in response to novelty and the conditioned locomotor effects of nicotine.

[5] Benowitz NL. Annu Rev Pharmacol Toxicol. Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics.

[6] Nordberg A, et al. J Neurochem. Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).

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