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NE 10790

Cat. No. M28574

All AbMole products are for research use only, cannot be used for human consumption.

NE 10790 Structure
Synonym:

3-PEHPC

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Quality Control & Documentation
Biological Activity

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

Chemical Information
Molecular Weight 247.14
Formula C8H10NO6P
CAS Number 152831-36-2
Form Solid
Solubility (25°C) 0.1 M NaOH : 20 mg/mL (ultrasonic and adjust pH to 6 with NaOH)
Water 5 mg/mL (ultrasonic and adjust pH to 6 with NaOH)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] William Stein, et al. J Heart Lung Transplant. Prevention of transplant coronary artery disease by prenylation inhibitors

[2] Sanna S Virtanen, et al. Cell Biol Int. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells

[3] Andreas Hald, et al. Int J Cancer. Cancer-induced bone loss and associated pain-related behavior is reduced by risedronate but not its phosphonocarboxylate analog NE-10790

[4] Pierrick G J Fournier, et al. Cancer Res. Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo

[5] E R van Beek, et al. Bone. Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

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Keywords: NE 10790, 3-PEHPC supplier, inhibitors, activators

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