Free shipping on all orders over $ 500

NE 10790

Cat. No. M28574

All AbMole products are for research use only, cannot be used for human consumption.

NE 10790 Structure
Synonym:

3-PEHPC

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

Chemical Information
Molecular Weight 247.14
Formula C8H10NO6P
CAS Number 152831-36-2
Form Solid
Solubility (25°C) 0.1 M NaOH : 20 mg/mL (ultrasonic and adjust pH to 6 with NaOH)
Water 5 mg/mL (ultrasonic and adjust pH to 6 with NaOH)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] William Stein, et al. J Heart Lung Transplant. Prevention of transplant coronary artery disease by prenylation inhibitors

[2] Sanna S Virtanen, et al. Cell Biol Int. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells

[3] Andreas Hald, et al. Int J Cancer. Cancer-induced bone loss and associated pain-related behavior is reduced by risedronate but not its phosphonocarboxylate analog NE-10790

[4] Pierrick G J Fournier, et al. Cancer Res. Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo

[5] E R van Beek, et al. Bone. Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

Related Products
GAPDH-IN-1

GAPDH-IN-1 (GAPDH Inhibitor Compound F8) is a covalent inhibitor of GAPDH (IC50 = 39.31 µM). It viability of, and glucose metabolism in, HEK293 cells in a concentration-dependent manner.
O-acetylcamptothecin

O-acetylcamptothecin is a derivative of camptothecin, a naturally occurring alkaloid extracted from the bark of the Chinese tree Camptotheca acuminata. Camptothecin and its derivatives are primarily known for their potent anticancer properties, particularly through their action as inhibitors of topoisomerase I, an enzyme critical for DNA replication and transcription.
10-hydroxystearic acid

10-hydroxystearic acid is a hydroxy fatty acid.
SB-T-1214

SB-T-1214 is a new-generation taxoid. SB-T-1214 possesses significant activity against colon cancer spheroids induced by and enriched with drug resistant tumorigenic CD133high/CD44high cells and efficiently inhibited expression of the majority of stem cell-related genes.
NG-497

NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL.

  Catalog
Abmole Inhibitor Catalog




Keywords: NE 10790, 3-PEHPC supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.