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NAS-181 is a potent, selective antagonist at the rat 5-HT1B receptor (Ki = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo. Increases subthalamic nucleus-triggered complex EPSCs and burst firing in SNr GABA neurons
| Molecular Weight | 538.63 |
| Formula | C19H26N2O4.2CH3SO3H |
| CAS Number | 1217474-40-2 |
| Solubility (25°C) | Water 53.86 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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