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Narasin

Cat. No. M21302
Narasin Structure
Synonym:

Monteban

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Biological Activity

Narasin is a cationic ion carrier and anticoccidial agent. narasin inhibits NF-κB signaling and induces apoptosis (tumor cell death), it has activity against gram-positive bacteria, anaerobic bacteria, mycoplasma and coccidia, and it also has antiviral effects.

Chemical Information
Molecular Weight 765.03
Formula C43H72O11
CAS Number 55134-13-9
Solubility (25°C) DMSO : 25 mg/mL
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Letcia Carolina Bortolanza Soares, et al. Transl Anim Sci. Effects of narasin supplementation frequency on intake, ruminal fermentation parameters, and nutrient digestibility of Bos indicus Nellore steers fed with forage-based diets

[2] Daniel M Polizel, et al. Transl Anim Sci. Effects of narasin supplementation on dry matter intake and rumen fermentation characteristics of Bos indicus steers fed a high-forage diet

[3] B J Kerr, et al. J Anim Sci. Narasin effects on energy, nutrient, and fiber digestibility in corn-soybean meal or corn-soybean meal-dried distillers grains with solubles diets fed to 16-, 92-, and 141-kg pigs

[4] Ghada Bouguerra, et al. Cell Physiol Biochem. Stimulation of Eryptosis by Narasin

[5] June Su Yin Low, et al. Antivir Ther. Narasin, a novel antiviral compound that blocks dengue virus protein expression

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