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Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract. Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 5-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG.
| Molecular Weight | 741.82 |
| Formula | C36H55NO15 |
| CAS Number | 1354744-91-4 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. JAMA. Naloxegol (Movantik) for Opioid-Induced Constipation
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