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N-Acetyl-L-methionine

Cat. No. M10149
N-Acetyl-L-methionine Structure
Synonym:

NAM

Size Price Availability Quantity
1g USD 25  USD25 In stock
2g USD 35  USD35 In stock
5g USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine.

Chemical Information
Molecular Weight 191.25
Formula C7H13NO3S
CAS Number 65-82-7
Form Solid
Solubility (25°C) Soluble in Water
Soluble in methanol
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ronald O Ball, et al. J Nutr. The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans

[2] J T Rotruck, et al. J Nutr. Effects of excess dietary l-methionine and N-acetyl-l-methionine on growing rats

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Keywords: N-Acetyl-L-methionine, NAM supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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