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MPP dihydrochloride

Cat. No. M14634
MPP dihydrochloride Structure
Size Price Availability Quantity
5mg USD 420  USD420 In stock
10mg USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

MPP dihydrochloride is a highly selective estrogen receptor alpha (ERα) antagonist. MPP dihydrochloride reduces the ratio of p-ERα/ERα.

Chemical Information
Molecular Weight 542.5
CAS Number 911295-24-4
Solubility (25°C) DMSO 30 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Marcela Islas-Cortez, et al. Characterization of the antiapoptotic effect of copper sulfate on striatal and midbrain damage induced by MPP + in rats

[2] Huaide Liu, et al. Protective Effect of Fucoidan against MPP +-Induced SH-SY5Y Cells Apoptosis by Affecting the PI3K/Akt Pathway

[3] Moiss Rubio-Osornio, et al. Copper sulfate pretreatment prevents mitochondrial electron transport chain damage and apoptosis against MPP +-induced neurotoxicity

[4] Ekaterine Tskitishvili, et al. Estrogen receptors and estetrol-dependent neuroprotective actions: a pilot study

[5] Moiss Rubio-Osornio, et al. Induction of ferroxidase enzymatic activity by copper reduces MPP+-evoked neurotoxicity in rats

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Keywords: MPP dihydrochloride supplier, Estrogen Receptor, inhibitors, activators


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