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MPEG-2000-DSPE sodium

Cat. No. M25518
MPEG-2000-DSPE sodium Structure
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Biological Activity

MPEG-2000-DSPE sodium is a phospholipid PEG conjugate, has both hydrophilicity and hydrophobility. MPEG-2000-DSPE sodium is used in the synthesis of liposomes, increases the hydrophilicity on the surface of liposomes, consequently increasing the longevity of liposomes in the blood circulation for the study of anticancer and antimalarial agents.

Chemical Information
Formula C45H87NNaO11P
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Elaheh Mirhadi, et al. Sci Rep. Redox-sensitive doxorubicin liposome: a formulation approach for targeted tumor therapy

[2] Jessy Shaji, et al. Pharm Nanotechnol. PEGylated Liposomes of Meloxicam: Optimization by Quality by Design, in vitro Characterization and Cytotoxicity Evaluation

[3] Sweta Modi, et al. J Control Release. Enhanced active liposomal loading of a poorly soluble ionizable drυg using supersaturated drυg solutions

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