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MK-8033 

Cat. No. M27598

All AbMole products are for research use only, cannot be used for human consumption.

MK-8033  Structure

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Quality Control & Documentation
Biological Activity

MK-8033 is an orally active ATP competitive c-Met/Ron dual inhibitor (IC50s: 1 nM (c-Met),7 nM (Ron)), with preferential binding to the activated kinase conformation. MK-8033 can be used in the research of cancers, such as breast and bladder cancers, non-small cell lung cancers (NSCLCs).

Chemical Information
Molecular Weight 471.53
Formula C25H21N5O3S
CAS Number 1001917-37-8
Form Solid
Solubility (25°C) DMSO ≥ 46 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Vicki L Keedy, et al. Invest New Drugs. First-in-human phase I dose escalation study of MK-8033 in patients with advanced solid tumors

[2] Nikita V Chukanov, et al. Acta Crystallogr B Struct Sci Cryst Eng Mater. Crystal structure of the OH-dominant gadolinite-(Y) analogue (Y,Ca)2(Fe,□)Be2Si2O8(OH,O)2 from Heftetjern pegmatite, Norway

[3] Chandrani Chattopadhyay, et al. PLoS One. Simultaneous inhibition of the HGF/MET and Erk1/2 pathways affect uveal melanoma cell growth and migration

[4] Alan B Northrup, et al. J Med Chem. Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met

[5] Vikas Bhardwaj, et al. J Thorac Oncol. C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression

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  Catalog
Abmole Inhibitor Catalog




Keywords: MK-8033  supplier, c-Met, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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