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MK-571 sodium salt is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). MK-571 sodium salt antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium salt is also an inhibitor of multidrug resistance protein-1 (MRP1) mediated transport, it augments the effects of cytotoxic agents on malignant cells in vitro.
| Molecular Weight | 537.07 |
| Formula | C26H26ClN2NaO3S2 |
| CAS Number | 115103-85-0 |
| Solubility (25°C) | Water 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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