Free shipping on all orders over $ 500

MJC13

Cat. No. M8301

All AbMole products are for research use only, cannot be used for human consumption.

MJC13 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

MJC13 inhibits the positive regulation of androgen receptor (AR) signaling by the cochaperone protein FKBP52. The molecule inhibits hormone-induced dissociation of the FKBP52, nuclear translocation of AR and AR dependent gene expression. MJC13 inhibits proliferation of the androgen-dependent prostate cancer cell lines LNCaP and LAPC4.

Chemical Information
Molecular Weight 272.17
Formula C13H15Cl2NO
CAS Number 200709-97-3
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Keisuke Maeda, et al. FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells

[2] Ji Ho Suh, et al. Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists

[3] Cheryl Storer Samaniego, et al. The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling

[4] Su Liang, et al. Quantification of a New Anti-Cancer Molecule MJC13 Using a Rapid, Sensitive, and Reliable Liquid Chromatography-Tandem Mass Spectrometry Method

[5] Su Liang, et al. Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer

Related Products
DSPE-PEG-FA

DSPE-PEG2K-FA is a PEG derivative containing folic acid. DSPE-PEG2K-FA has a targeting effect and can bind to folic acid receptors in cancer cells. DSPE-PEG2K-FA forms micelles/lipid bilayers and can be used in research on targeted drug delivery systems.
Lifastuzumab

Lifastuzumab is a humanized anti-NaPi2b IgG1 monoclonal antibody.
GPVI antagonist 1

GPVI antagonist 1 is a glycoprotein VI (GPVI) platelet receptor antagonist. GPVI antagonist 1 inhibits collagen-induced platelet aggregation with an IC50 of 25.3 μM.
MPSD TFA

MPSD TFA (MARCKS-ED TFA) is a 25-amino acid peptide based on the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). MPSD TFA can sense membrane curvature and recognize phosphatidylserine. MPSD TFA can be utilized as biological probe to study membrane shape and lipid composition.
4-Nitro-2,1,3-benzoselenadiazole

4-Nitro-2,1,3-benzoselenadiazole is a biochemical material that can be used in scientific research.
  Catalog
Abmole Inhibitor Catalog




Keywords: MJC13 supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.