MitoTracker Deep Red FM is a red fluorescent dye that selectively accumulates in the mitochondrial matrix and covalently binds to mitochondrial proteins by reacting with the free thiol groups of cysteine residues, allowing staining of the mitochondrial membrane potential independently of the membrane potential. Excitation/emission wavelength 644/665 nm.
Molecular Weight | 543.57 |
Formula | C34H36Cl2N2 |
CAS Number | 873315-86-7 |
Form | Solid |
Solubility (25°C) | DMSO >125 mg/mL |
Storage | -20°C, protect from light |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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