The MitoSOX Red Mitochondrial Superoxide Indicator, a cationic derivative of dihydroethidium, is designed to detect Mitochondrial Superoxide in living cells with high specificity. It is a new type of fluorescent probe specifically targeting live cell line sites. It has membrane permeability and can bind mitochondria quickly and selectively. Once entering mitochondria, it is oxidized by superoxide and binds to nucleic acid to produce strong red fluorescence. Its maximum excitation/emission wavelength is 510/580nm.
Nat Commun. 2023 Sep 2;14(1):5360.
FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination
MitoSOX Red Mitochondrial Superoxide Indicator purchased from AbMole
| Molecular Weight | 759.71 |
| Formula | C43H43N3IP |
| Solubility (25°C) | DMSO: 5mM |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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