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The MitoSOX Red Mitochondrial Superoxide Indicator, a cationic derivative of dihydroethidium, is designed to detect Mitochondrial Superoxide in living cells with high specificity. It is a new type of fluorescent probe specifically targeting live cell line sites. It has membrane permeability and can bind mitochondria quickly and selectively. Once entering mitochondria, it is oxidized by superoxide and binds to nucleic acid to produce strong red fluorescence. Its maximum excitation/emission wavelength is 510/580nm.
| Molecular Weight | 759.71 |
| Formula | C43H43N3IP |
| Solubility (25°C) | DMSO：5mM |
| Storage | -20°C , protect from light , dry , sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Fluorescent Dye Products |
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| Mito Red
Mito Red is a cell membrane permeable rhodamine based dye. It localizes mitochondria, and emits red fluorescence. λex 569 nm; λem 594 nm in DMSO |
| 6-CFDA
6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. |
| 5-CFDA
5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. |
| 5(6)-FAM SE
5(6)-FAM SE is an amine-reactive green fluorescent dye widely used for labeling proteins or other molecules that contain a primary or secondary aliphatic amine. |
| 5-FAM SE
5-FAM SE is a green fluorescent labeling reagent used for labeling peptides, proteins and nucleotides. 5-FAM SE can react with amines and can yield stable amine conjugates. |
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