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Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy. Mitochonic acid 5 regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. Mitochonic Acid 5 is a derivative of the plant hormone indole-3-acetic acid. Administration of Mitochonic acid 5 (MA-5) to an ischemia-reperfusion injury model and a cisplatin-induced nephropathy model improved renal function. Oral administration of Mitochonic acid 5 increases the plasma concentration in a dose-response manner at the peak time of 1 hour.
| Molecular Weight | 329.30 |
| Formula | C18H13F2NO3 |
| CAS Number | 1354707-41-7 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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