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Tetradecyltrimethylammonium bromide is a dynamin inhibitor; inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Tetradecyltrimethylammonium bromide targets the dynamin-phospholipid interaction. Tetradecyltrimethylammonium bromide inhibits receptor-mediated endocytosis of epidermal growth factor (EGF) in non-neuronal cells; also inhibits synaptic vesicle endocytosis. Tetradecyltrimethylammonium bromide displays dynamin I-inhibitory activity similar to OctMAB.
| Molecular Weight | 336.39 |
| Formula | C17H38BrN |
| CAS Number | 1119-97-7 |
| Solubility (25°C) | Water 68 mg/mL |
| Storage | RT, dry, sealed |
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