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(-)-Taxifolin

Cat. No. M11479
(-)-Taxifolin Structure
Synonym:

(-)-Dihydroquercetin

Size Price Availability Quantity
5mg USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

(-)-Taxifolin is a low activity isomer of Taxifolin. Taxifolin has important anti-tyrosinase activity. Taxifolin effectively inhibited collagenase with IC50 of 193.3 μM. Taxifolin is an important natural compound with anti-fibrosis effects. Taxifolin is a free radical scavenger with antioxidant capacity.

Chemical Information
Molecular Weight 304.25
Formula C15H12O7
CAS Number 111003-33-9
Solubility (25°C) N/A
Storage 2-8℃
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fernanda Cristina Stenger Moura, et al. Pharmaceutics. Exploring Taxifolin Polymorphs: Insights on Hydrate and Anhydrous Forms

[2] Satoshi Saito, et al. Front Pharmacol. Taxifolin: A Potential Therapeutic Agent for Cerebral Amyloid Angiopathy

[3] Zi-Ying Zhan, et al. Food Funct. Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis

[4] Sandra Gunesch, et al. Redox Biol. 7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo

[5] Christudas Sunil, et al. Phytochemistry. An insight into the health-promoting effects of taxifolin (dihydroquercetin)

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Keywords: (-)-Taxifolin, (-)-Dihydroquercetin supplier, Tyrosinase, inhibitors, activators


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