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(-)-Menthol

Cat. No. M20425
(-)-Menthol Structure
Synonym:

L-Menthol|Levomenthol|Menthomenthol|Menthacamphor

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Biological Activity

(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.

Chemical Information
Molecular Weight 156.27
Formula C10H20O
CAS Number 2216-51-5
Solubility (25°C) DMSO 31 mg/mL
Water 16 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Robert J Wickham. Nicotine Tob Res. The Biological Impact of Menthol on Tobacco Dependence

[2] Nancy C Jao, et al. Nicotine Tob Res. Menthol Cigarettes, Tobacco Dependence, and Smoking Persistence: The Need to Examine Enhanced Cognitive Functioning as a Neuropsychological Mechanism

[3] F Kervinio, et al. Prog Urol. [Menthol in the control of bladder activity: A review]

[4] Guy P P Kamatou, et al. Phytochemistry. Menthol: a simple monoterpene with remarkable biological properties

[5] Youn Ok Lee, et al. Tob Control. Menthol: putting the pieces together

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Keywords: (-)-Menthol, L-Menthol|Levomenthol|Menthomenthol|Menthacamphor supplier, Opioid Receptor, inhibitors, activators


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