(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.
|Solubility (25°C)||DMSO 31 mg/mL
Water 16 mg/mL
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Robert J Wickham. Nicotine Tob Res. The Biological Impact of Menthol on Tobacco Dependence
 Nancy C Jao, et al. Nicotine Tob Res. Menthol Cigarettes, Tobacco Dependence, and Smoking Persistence: The Need to Examine Enhanced Cognitive Functioning as a Neuropsychological Mechanism
 F Kervinio, et al. Prog Urol. [Menthol in the control of bladder activity: A review]
 Guy P P Kamatou, et al. Phytochemistry. Menthol: a simple monoterpene with remarkable biological properties
 Youn Ok Lee, et al. Tob Control. Menthol: putting the pieces together
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