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Milatuzumab

Cat. No. M25272

All AbMole products are for research use only, cannot be used for human consumption.

Milatuzumab Structure
Synonym:

hLL1 MEDI-115

Size Price Availability Quantity
100ug USD 160  USD160 In stock
1mg USD 340  USD340 In stock
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Quality Control & Documentation
Biological Activity

Milatuzumab (hLL1; MEDI-115) is a humanized anti-CD74 monoclonal antibody. CD74, a integral membrane protein, is associated with the promotion of B-cell growth and survival. Milatuzumab causes free radical oxygen generation, and loss of mitochondrial membrane potential. Milatuzumaba also decreases CD20/CD74 aggregates and cell adhesion, to lead to cell death.

Chemical Information
CAS Number 899796-83-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Serengulam V Govindan, et al. Mol Cancer Ther. Milatuzumab-SN-38 conjugates for the treatment of CD74+ cancers

[2] Erin Hertlein, et al. Blood. Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells

[3] Zuzana Berkova, et al. Expert Opin Investig Drugs. Milatuzumab - a promising new immunotherapeutic agent

[4] Rhona Stein, et al. Clin Cancer Res. Combining milatuzumab with bortezomib, doxorubicin, or dexamethasone improves responses in multiple myeloma cell lines

[5] Tomer Mark, et al. Expert Opin Investig Drugs. Milatuzumab: a promising new agent for the treatment of lymphoid malignancies

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Keywords: Milatuzumab, hLL1 MEDI-115 supplier, inhibitors, activators

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