Free shipping on all orders over $ 500

MI-3

Cat. No. M11463
MI-3 Structure
Synonym:

Menin-MLL inhibitor 3

Size Price Availability Quantity
5mg USD 172  USD172 In stock
10mg USD 270  USD270 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Mi-3 (Menin-mLL inhibitor 3) is an effective and high affinity menin-MLL inhibitor with IC50 value of 648 nM and Kd value of 201 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 375.55
Formula C18H25N5S2
CAS Number 1271738-59-0
Purity >99%
Solubility DMSO ≥ 10 mg/mL
Storage at -20°C
Related Epigenetic Reader Domain Products
FHD-286

FHD-286 is the first dual inhibitor of SMARCA2/SMARCA4. , can be used for metastatic melanoma and advanced hematological tumor research.

Alobresib

Alobresib (GS-5829) is a BET bromine domain inhibitor that can be used in the study of recurrent and drug-resistant overexpressed c-Myc uterine serous carcinoma.

ZL0420

ZL0420 is a potent and selective BET bromine domain 4 (BRD4) inhibitor of BRD4 BD1 and BRD4 BD2 IC50 27 nM and 32 nM, respectively.

MS645

MS645 is a BET bromodomains (BrD) inhibitor for K of BRD4-BD1/BD2i The value is 18.4 nM. MS645 spatially limits the divalent inhibition of BRD4 BrDs, resulting in sustained inhibition of BRD4 transcriptional activity in solid tumor cells.

LT052

LT052 is a highly selective BET BD1 inhibitor IC50 87.7 nM. LT052 exhibits nanomolar-grade inhibitory activity of BRD4 BD1 and is 138 times more selective than BRD4 BD2 (IC).50=12.130 μM)。 LT052 has anti-inflammatory activity and can be used in acute gouty arthritis studies.

  Catalog
Abmole Inhibitor Catalog




Keywords: MI-3, Menin-MLL inhibitor 3 supplier, Epigenetic Reader Domain, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.