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Cat. No. M11463
MI-3 Structure

Menin-MLL inhibitor 3

Size Price Availability Quantity
5mg USD 172  USD172 In stock
10mg USD 270  USD270 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Mi-3 (Menin-mLL inhibitor 3) is an effective and high affinity menin-MLL inhibitor with IC50 value of 648 nM and Kd value of 201 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 375.55
Formula C18H25N5S2
CAS Number 1271738-59-0
Purity >99%
Solubility DMSO ≥ 10 mg/mL
Storage at -20°C
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Keywords: MI-3, Menin-MLL inhibitor 3 supplier, Epigenetic Reader Domain, inhibitors

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