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Metoclopramide hydrochloride hydrate

Cat. No. M4942
Metoclopramide hydrochloride hydrate Structure
Synonym:

Metoclopramide monohydrochloride monohydrate

Size Price Availability Quantity
100mg USD 60  USD60 In stock
200mg USD 80  USD80 In stock
500mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic. Metoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. It can be used to construct animal models of hyperprolactinemia.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male albino Swiss mice
Formulation saline solution
Dosages 20 mg/kg
Administration i.p.
Chemical Information
Molecular Weight 354.27
Formula C14H25Cl2N3O3
CAS Number 54143-57-6
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cavero-Redondo I, et al. J Clin Nurs. Risk of extrapyramidal side effects comparing continuous vs. bolus intravenous metoclopramide administration: a systematic review and meta-analysis of randomised controlled trials.

[2] Mohammad FK, et al. Pharmacol Rep. Antinociception by metoclopramide, ketamine and their combinations in mice.

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Keywords: Metoclopramide hydrochloride hydrate, Metoclopramide monohydrochloride monohydrate supplier, Animal Modeling, inhibitors, activators


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