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Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase. Methyl rosmarinate downregulates the phosphorylation levels of ERK, JNK, p38, Smad2 and Smad3. Methyl rosmarinate activates erythrocyte BPGM and promotes the production of 2,3-BPG. Methyl rosmarinate induces apoptosis of fibroblasts. Methyl rosmarinate prolongs the survival time of hypoxic mice. Methyl rosmarinate improves insulin sensitivity. Methyl rosmarinate binds to SARS-CoV-2 3CLpro and inhibits viral replication. Methyl rosmarinate induces glioblastoma cell death. Methyl rosmarinate activates the TGR5/AMPK axis and reduces the levels of ROS and MDA. Methyl rosmarinate shows inhibitory activity against MMP-1.
| Molecular Weight | 374.34 |
| Formula | C19H18O8 |
| CAS Number | 99353-00-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light |
| Related Tyrosinase Products |
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Deoxyarbutin can effectively inhibit tyrosinase activity and melanin synthesis, and obtain significant and lasting whitening effect, with strong antioxidant effect. |
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Trifolirhizin is a pterocarpan flavonoid isolated from the root of Sophora flavescoreae. Trifolirhizin showed high tyrosinase inhibitory activity with IC50 of 506 μM. Trifolirhizin has potential anti-inflammatory and anticancer activities. |
| XMD8-87
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| Dihydromorin
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal melanocytes, indicating that a non-tumor melanocyte system is more suitable for the screening of hypopigmenting agents. |
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