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Methionine sulfoxide

Cat. No. M11209
Methionine sulfoxide  Structure
Synonym:

METHIONINE SULFOXIDE, DL-;LABOTEST-BB LT00053249

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Quality Control & Documentation
Biological Activity

Methionine sulfoxide is an oxidation product of methionine with reactive oxygen species that can be used as a biomarker of oxidative stress in the body.

Chemical Information
Molecular Weight 165.21
Formula C5H11NO3S
CAS Number 62697-73-8
Solubility (25°C) Water ≥ 200 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Darren Leahy, et al. Molecules. Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase

[2] Jackob Moskovitz, et al. Amino Acids. Methionine sulfoxide and the methionine sulfoxide reductase system as modulators of signal transduction pathways: a review

[3] Vanessa Reusche, et al. Chembiochem. Effect of Methionine Sulfoxide on the Synthesis and Purification of Aggregation-Prone Peptides

[4] Melissa Reiterer, et al. Free Radic Res. Methionine sulfoxide reductase (Msr) dysfunction in human brain disease

[5] Sreya Tarafdar, et al. Free Radic Biol Med. Drosophila methionine sulfoxide reductase A (MSRA) lacks methionine oxidase activity

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Keywords: Methionine sulfoxide , METHIONINE SULFOXIDE, DL-;LABOTEST-BB LT00053249 supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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