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Met-Enkephalin

Cat. No. M9268
Met-Enkephalin Structure
Synonym:

H-Tyr-Gly-Gly-Phe-Met-OH

Size Price Availability Quantity
10mg USD 60  USD60 In stock
25mg USD 110  USD110 In stock
50mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Met-Enkephalin is an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. Met-Enkephalin (H-Tyr-Gly-Gly-Phe-Met-OH) changes the tumor microenvironment by binding to opioid receptor on or in cancer cells.

Chemical Information
Molecular Weight 573.66
Formula C27H35N5O7S
CAS Number 58569-55-4
Solubility (25°C) DMSO: ≥ 23 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhao D, et al. Int Immunopharmacol. Methionine enkephalin, its role in immunoregulation and cancer therapy.

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Keywords: Met-Enkephalin, H-Tyr-Gly-Gly-Phe-Met-OH supplier, Opioid Receptor, inhibitors, activators


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