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MeO-Suc-Arg-Pro-Tyr-pNA

Cat. No. M43279
MeO-Suc-Arg-Pro-Tyr-pNA Structure
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Biological Activity

MeOSuc-Arg-Pro-Tyr-pNA is a biological active peptide.

Chemical Information
Molecular Weight 668.7
Formula C31H40N8O9
CAS Number 82564-18-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sung-Ho Lee et al. Antioxidants (Basel). Partial Purification and Biochemical Evaluation of Protease Fraction (MA-1) from Mycoleptodonoides aitchisonii and Its Fibrinolytic Effect

[2] G Pejler et al. Biochemistry. Mechanism by which heparin proteoglycan modulates mast cell chymase activity

[3] R Kurkela et al. Biotechnology (N Y). Expression of active, secreted human prostate-specific antigen by recombinant baculovirus-infected insect cells on a pilot-scale

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