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Mefloquine hydrochloride is a quinoline antimalarial compound that is structurally related to the antiarrhythmic agent quinidine. Mefloquine inhibited KvLQT1/minK channel currents with an IC50 value of approximately 1 microM. Mefloquine hydrochloride inhibits several mutant hemichannel forms implicated in KID syndrome when expressed in Xenopus laevis oocytes (IC50∼16 μM), using an extracellular divalent cation, zinc (Zn++), as a nonspecific positive control for comparison (IC50∼3 μM). Mefloquine slowed the activation rate of KvLQT1/minK and more block was evident at lower membrane potentials compared with higher ones.
| Molecular Weight | 414.77 |
| Formula | C17H17ClF6N2O |
| CAS Number | 51773-92-3 |
| Solubility (25°C) | DMSO 60 mg/mL Ethanol 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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