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MCLA hydrochloride

Cat. No. M13792
MCLA hydrochloride Structure
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Biological Activity

MCLA hydrochloride is a chemiluminescent reagent which can be used to quantify aqueous concentrations of superoxide.

Chemical Information
Molecular Weight 291.73
CAS Number 128322-44-1
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Michael J Haas, et al. Int J Cardiol. Angiotensin II receptor one (AT1) mediates dextrose induced endoplasmic reticulum stress and superoxide production in human coronary artery endothelial cells

[2] Michael J Haas, et al. Am J Ther. Beta Blockers Suppress Dextrose-Induced Endoplasmic Reticulum Stress, Oxidative Stress, and Apoptosis in Human Coronary Artery Endothelial Cells

[3] Yong Ma, et al. Luminescence. Study on the generation mechanism of reactive oxygen species on calcium peroxide by chemiluminescence and UV-visible spectra

[4] Keiichi Kuwahara, et al. Cornea. Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro

[5] L Zhang, et al. J Biol Chem. Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria

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