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M62812 is a tLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.
| Molecular Weight | 330.23 |
| Formula | C13H11N3OS.2HCl |
| CAS Number | 613263-00-6 |
| Solubility (25°C) | DMSO 16.51 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Pick, et al. ChemMedChem. Specific inhibitors of the breast cancer resistance protein (BCRP).
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