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M‑1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression. M-1121 (0~100 nM; 24 hours; MV4;11 cells) drives dose-dependent down-regulation of HOXA9 and MEIS1 gene expression in the MLL-rearranged MV4;11 leukemia cell line. M-1121 establishes covalent interactions with Cysteine 329 located in the MLL binding pocket of menin and potently inhibits growth of acute leukemia cell lines carrying MLL translocations with no activity in cell lines with wild-type MLL.
| Molecular Weight | 793.00 |
| Formula | C42H57FN6O6S |
| CAS Number | 2377337-93-2 |
| Solubility (25°C) | DMSO |
| Storage | -20°C, protect from light, dry, sealed |
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