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Lyso-Tracker Red

Cat. No. M21524
Lyso-Tracker Red  Structure
Synonym:

LysoTracker Red; LysoTracker Red DND-99

Size Price Availability Quantity
50uL USD 160  USD160 In stock
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Quality Control & Documentation
Biological Activity

Lyso-Tracker Red is an eosinophilic fluorescent probe with a maximum excitation wavelength of 577nm and a maximum emission wavelength of 590nm. Lyso-Tracker Red must be at very low concentrations (usually about 50nM) to achieve excellent selectivity.

Chemical Information
Molecular Weight 399.25
Formula C20H24BF2N5O
CAS Number 231946-72-8
Form Solid
Solubility (25°C) DMSO 5 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jiahuan Tan, et al. Stem Cell Res Ther. CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis

[2] Li Ruan, et al. Anal Chim Acta. A series of meso amide BODIPY based lysosome-targeting fluorescent probe with high photostability and sensitivity

[3] Pengfei Xu, et al. J Neuroinflammation. TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage

[4] Pan Liu, et al. Bioconjug Chem. Cyclotriphosphazene-Based "Butterfly" Fluorescence Probe for Lysosome Targeting

[5] Si Chen, et al. Front Mol Neurosci. 27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells

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Keywords: Lyso-Tracker Red , LysoTracker Red; LysoTracker Red DND-99 supplier, Fluorescent Dye, inhibitors, activators


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