Free shipping on all orders over $ 500

LY2922470

Cat. No. M10851

All AbMole products are for research use only, cannot be used for human consumption.

LY2922470  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

LY2922470 is an effective, selective, orally potent GPR40 agonist that acts on human GPR40, mouse GPR40, and rat GPR40 EC50 The values are 7 nM, 1 nM, and 3 nM, respectively. LY2922470 lowers blood glucose levels while significantly increasing insulin and GLP-1, potentially for use in the study of type 2 diabetes mellitus (T2DM).

Chemical Information
Molecular Weight 475.6
Formula C28H29NO4S
CAS Number 1423018-12-5
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage 4°C,protect from light ,dry ,sealed
References

[1] Joo Won Kim, et al. Diabetes Metab J. GPR40 Agonism Modulates Inflammatory Reactions in Vascular Endothelial Cells

[2] Chafiq Hamdouchi, et al. J Med Chem. The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)

[3] Zheng Li, et al. Expert Opin Investig Drugs. Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development

Related Products
PCL-PEG-MAL

PCL-PEG-MAL is an amphiphilic block copolymer consisting of polycaprolactone (PCL), polyethylene glycol (PEG) and maleimide (MAL) functional groups. PCL-PEG-MAL is used in targeted delivery systems, surface modification of nanomaterials, functionalisation of biomaterials and biosensing technologies for specific chemical linkages or biomolecular immobilisation.

DSPE-PEG-Streptavidin

DSPE-PEG-Streptavidin is an important biocoupling molecule widely used in biomedical research, especially in drug delivery, targeted therapies, immunodiagnostics and biosensors. Through the specific binding between streptavidin and biotin, DSPE-PEG-Streptavidin can help to achieve efficient loading and targeted action in targeted delivery systems. In addition, the molecule is widely used in molecular imaging and bioassays, especially for molecular recognition using the strong affinity between streptavidin and biotin in assay platforms that require high sensitivity and specificity.

E7107

E7107 is a first-in-class precursor messenger ribonucleic acid (pre-mRNA) spliceosome inhibitor.

KL044

KL044 is a stabilizer of the clock protein cryptochrome (CRY). KL044 is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity.

2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide

2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide is a biochemical material that can be used in scientific research.

  Catalog
Abmole Inhibitor Catalog




Keywords: LY2922470 supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.