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LY2795050

Cat. No. M21655

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LY2795050 Structure
Synonym:

LY-2795050

Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 360  USD360 In stock
25mg USD 630  USD630 In stock
50mg USD 850  USD850 In stock
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Quality Control & Documentation
Biological Activity

LY2795050 is a short-acting selective κ(kappa)-opioid receptor (KOR) antagonist. LY2795050 has high affinity for the KOR with Ki value of 0.72 nM. LY2795050 can be used for the research of central nervous system dysfunction. U50,488 produced dose-dependent grooming deficits in male and female mice, and LY2795050 prevented these effects. In contrast, LY2795050 decreased immobility in the FST in males at a dose of 0.1 mg/kg, but not in females, up to a dose of 0.32 mg/kg. Also, LY2795050 (0.32 mg/kg) prevented and also reversed the locomotor-depressant effects of U50,488 (10 mg/kg), in males and females.

Chemical Information
Molecular Weight 407.89
Formula C23H22ClN3O2
CAS Number 1346133-08-1
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Eduardo R Butelman, et al. J Psychopharmacol. Profile of a short-acting κ-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: sex comparison in mice

[2] Ming-Qiang Zheng, et al. J Nucl Med. Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging

[3] Kam Leung. [ Carbonyl-11C](S)-3-chloro-4-(4-((2-(pyridine-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide

[4] Eduardo R Butelman, et al. J Psychopharmacol. Profile of a short-acting κ-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: sex comparison in mice

[5] Ming-Qiang Zheng, et al. J Nucl Med. Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imaging

[6] Tanpreet Kaur, et al. Org Process Res Dev. Strategies for the Production of [11C]LY2795050 for Clinical Use

[7] Lingyun Yang, et al. ACS Med Chem Lett. Radiosynthesis of [11C]LY2795050 for Preclinical and Clinical PET Imaging Using Cu(II)-Mediated Cyanation

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Keywords: LY2795050, LY-2795050 supplier, Opioid Receptor, inhibitors, activators

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