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LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.
| Molecular Weight | 538.52 |
| CAS Number | 945976-76-1 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 34 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Claire M Ervin, et al. Clinical trials in irritable bowel syndrome: a review
[3] Jan Tack, et al. Targeting serotonin synthesis to treat irritable bowel syndrome
| Related Tryptophan Hydroxylase Products |
|---|
| ACT-678689
ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM. |
| Telotristat
Telotristat (LP-778902) is a potent tryptophan hydroxylase inhibitor with an in vivo IC50 of 0.028 μM. |
| Telotristat ethyl
Telotristat ethyl, also known as LX1606, is an oral serotonin synthesis inhibitor or peripheral tryptophan hydroxylase (TPH) inhibitor. |
| Telotristat Etiprate
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. |
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