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Lupeol acetate

Cat. No. M17785
Lupeol acetate Structure
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Biological Activity

Lupeol acetate

Chemical Information
CAS Number 1617-68-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Angel D Herrera-Espaa, et al. Nat Prod Res. Lupeol acetate isolated from Chrysophyllum cainito L. fruit as a template for the synthesis of N-alkyl-arylsulfonamide derivatives and their synergistic effects with metronidazole against Trichomonas vaginalis

[2] Shabnam Javed, et al. Sci Rep. Lupeol acetate as a potent antifungal compound against opportunistic human and phytopathogenic mold Macrophomina phaseolina

[3] Rosnani Nasution, et al. J Adv Pharm Technol Res. Isolation of lupeol acetate from fruit peels of Artocarpus camansi

[4] Bo Zhu, et al. J Ethnopharmacol. The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review

[5] Wei-Hsun Wang, et al. Biomed Pharmacother. Lupeol acetate ameliorates collagen-induced arthritis and osteoclastogenesis of mice through improvement of microenvironment

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