Lithospermoside (Griffonin) is a natural product isolated from stem bark of Ochna Schweinfurthiana F. Hoffm.
| Molecular Weight | 329.30 |
| Formula | C14H19NO8 |
| CAS Number | 63492-69-3 |
| Form | Solid |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Savio S Elo-Manga, et al. Chemical constituents of the leaves of Campylospermum elongatum
[5] D M. Fort, et al. Lithospermoside from Bauhinia fassoglensis (Fabaceae)
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