Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that may be used in studies related to type 2 diabetes. Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells.
| Cell Experiment | |
|---|---|
| Cell lines | Raw264.7 macrophage cells |
| Preparation method | Raw264.7 macrophage cells are cultured in DMEM supplemented with 10% fetal bovine serum in a humidified 37°C incubator with 5% CO2. The cells are incubated with oxLDL (50 μg/mL), Liraglutide (0.1, 0.5, 1 and 2 nmol/L) or Exendin-3 (9-39) (1, 10 and 100 nM) alone, or in combination. |
| Concentrations | 0.1, 0.5, 1 and 2 nmol/L |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 3751.20 |
| Formula | C172H265N43O51 |
| CAS Number | 204656-20-2 |
| Form | Solid |
| Solubility (25°C) | Water 4 mg/mL (ultrasonic and warming and adjust pH to 4 with HCl) 0.1 M NaOH: 12 mg/mL (adjust pH to 8 with 0.1 M NaOH) |
| Storage | -20°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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