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Liraglutide

Cat. No. M45167

All AbMole products are for research use only, cannot be used for human consumption.

Liraglutide Structure
Size Price Availability Quantity
1mg USD 120  USD120 In stock
5mg USD 400  USD400 In stock
10mg USD 580  USD580 In stock
25mg USD 720  USD720 In stock
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Biological Activity

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that may be used in studies related to type 2 diabetes. Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells.

Protocol (for reference only)
Cell Experiment
Cell lines Raw264.7 macrophage cells
Preparation method Raw264.7 macrophage cells are cultured in DMEM supplemented with 10% fetal bovine serum in a humidified 37°C incubator with 5% CO2. The cells are incubated with oxLDL (50 μg/mL), Liraglutide (0.1, 0.5, 1 and 2 nmol/L) or Exendin-3 (9-39) (1, 10 and 100 nM) alone, or in combination.
Concentrations 0.1, 0.5, 1 and 2 nmol/L
Incubation time
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 3751.20
Formula C172H265N43O51
CAS Number 204656-20-2
Form Solid
Solubility (25°C) Water 4 mg/mL (ultrasonic and warming and adjust pH to 4 with HCl)
0.1 M NaOH: 12 mg/mL (adjust pH to 8 with 0.1 M NaOH)
Storage -20°C, dry, sealed
References

[1] Julie R Lundgren, et al. N Engl J Med. Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined

[2] Thomas A Wadden, et al. Obesity (Silver Spring). Liraglutide 3.0 mg and Intensive Behavioral Therapy (IBT) for Obesity in Primary Care: The SCALE IBT Randomized Controlled Trial

[3] Patrick M O'Neil, et al. Lancet. Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial

[4] Abdulreda MH, et al. Cell Metab. Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model.

[5] Matthew James Armstrong, et al. Lancet. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

[6] Lisbeth V Jacobsen, et al. Clin Pharmacokinet. Liraglutide in Type 2 Diabetes Mellitus: Clinical Pharmacokinetics and Pharmacodynamics

[7] Wang YG, et al. J Geriatr Cardiol. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.

[8] Gaspari T, et al. Diab Vasc Dis Res. A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model.

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Keywords: Liraglutide supplier, GLP Receptor, inhibitors, activators

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