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Cat. No. M11231

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LDC1267  Structure
Size Price Availability Quantity
5mg USD 78  USD78 In stock
10mg USD 127  USD127 In stock
25mg USD 225  USD225 In stock
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Quality Control & Documentation
Biological Activity

LDC1267 is a highly selective inhibitor of TAM (Tyro3,Axl and Mer) kinases with IC50 values of <5 nM/8 nM/29 nM against Tyro3/Axl/Mer, respectively.

Chemical Information
Molecular Weight 560.55
Formula C30H26F2N4O5
CAS Number 1361030-48-9
Form Solid
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month

[1] Daria Zdżalik-Bielecka, et al. Mol Cancer Res. Bemcentinib and Gilteritinib Inhibit Cell Growth and Impair the Endo-Lysosomal and Autophagy Systems in an AXL-Independent Manner

[2] Zaofeng Zou, et al. Evid Based Complement Alternat Med. Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone-Induced Demyelinating Model

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Glesatinib (MGCD265) is an orally active, potent MET/SMO dual inhibitor. Glesatinib, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC).

DS-1205b free base 

DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo.

Ningetinib Tosylate

Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

Abmole Inhibitor Catalog

Keywords: LDC1267 supplier, TAM Receptor, inhibitors, activators

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