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Lazertinib

Cat. No. M9938
Lazertinib Structure
Synonym:

YH-25448; GNS-1480

Size Price Availability Quantity
5mg USD 128  USD160 In stock
10mg USD 192  USD240 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Lazertinib, also known as YH-25448 and GNS-1480, is an oral active, highly potent, mutant-selective and irreversible EGFR Tyrosine-kinase inhibitors (TKIs) targets both the T790M mutation and activating EGFR mutations while sparing wild type-EGFR. Lazertinib (YH25448) has good blood brain barrier (BBB) penetration property.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 554.64
Formula C30H34N8O3
CAS Number 1903008-80-9
Purity >99%
Solubility DMSO 6 mg/mL
Storage at -20°C
References

[1] No authors listed. Cancer Discov. Lazertinib Is Safe and Effective in Non-Small Cell Lung Cancer

[2] Sohita Dhillon. Correction to: Lazertinib: First Approval

[3] Sohita Dhillon. Lazertinib: First Approval

[4] Misako Nagasaka, et al. Beyond Osimertinib: The Development of Third-Generation EGFR Tyrosine Kinase Inhibitors For Advanced EGFR+ NSCLC

[5] Myung-Ju Ahn, et al. Lazertinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer: results from the dose escalation and dose expansion parts of a first-in-human, open-label, multicentre, phase 1-2 study

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Keywords: Lazertinib, YH-25448; GNS-1480 supplier, EGFR/HER2, inhibitors

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