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Lazertinib

Cat. No. M9938

All AbMole products are for research use only, cannot be used for human consumption.

Lazertinib Structure
Synonym:

YH-25448; GNS-1480

Size Price Availability Quantity
1mg USD 50  USD50 In stock
5mg USD 115  USD115 In stock
10mg USD 200  USD200 In stock
25mg USD 300  USD300 In stock
50mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Lazertinib, also known as YH-25448 and GNS-1480, is an oral active, highly potent, mutant-selective and irreversible EGFR Tyrosine-kinase inhibitors (TKIs) targets both the T790M mutation and activating EGFR mutations while sparing wild type-EGFR. Lazertinib (YH25448) has good blood brain barrier (BBB) penetration property.

Chemical Information
Molecular Weight 554.64
Formula C30H34N8O3
CAS Number 1903008-80-9
Solubility (25°C) DMSO 6 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] No authors listed. Cancer Discov. Lazertinib Is Safe and Effective in Non-Small Cell Lung Cancer

[2] Sohita Dhillon. Correction to: Lazertinib: First Approval

[3] Sohita Dhillon. Lazertinib: First Approval

[4] Misako Nagasaka, et al. Beyond Osimertinib: The Development of Third-Generation EGFR Tyrosine Kinase Inhibitors For Advanced EGFR+ NSCLC

[5] Myung-Ju Ahn, et al. Lazertinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer: results from the dose escalation and dose expansion parts of a first-in-human, open-label, multicentre, phase 1-2 study

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  Catalog
Abmole Inhibitor Catalog




Keywords: Lazertinib, YH-25448; GNS-1480 supplier, EGFR/HER2, inhibitors, activators

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