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Lasiocarpine

Cat. No. M39122

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Lasiocarpine Structure

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Quality Control & Documentation
Biological Activity

Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide.

Chemical Information
Molecular Weight 411.49
Formula C21H33NO7
CAS Number 303-34-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Johanna Ebmeyer et al. Food Chem Toxicol. Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine

[2] Rosalind R Dalefield et al. Regul Toxicol Pharmacol. A 28-day oral toxicity study of echimidine and lasiocarpine in Wistar rats

[3] Muluneh M Fashe et al. Chem Res Toxicol. Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine

[4] National Toxicology Program. Natl Cancer Inst Carcinog Tech Rep Ser. Bioassay of lasiocarpine for possible carcinogenicity

[5] No authors listed. IARC Monogr Eval Carcinog Risk Chem Man. Lasiocarpine

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trans-Vaccenic acid

trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation.

Mead acid

Mead acid (5,8,11-Eicosatrienoic acid) is an unsaturated (Omega-9) fatty acid.
p-Cresol glucuronide

p-Cresol glucuronide is a metabolite of p-cresol, it is a prototype protein-bound uremic toxin.
Oleamide

Oleamide is an endogenous fatty acid amide.
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Keywords: Lasiocarpine supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

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